Polymorph formation from solvate desolvation |
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| Authors: | Beatrice Nicolaï P Espeau R Céolin M -A Perrin L Zaske J Giovannini F Leveiller |
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| Institution: | 1.Laboratoire de Chimie Physique, EA 4066,Faculté de Pharmacie,Paris,France;2.AstraZeneca R and D,Lund,Sweden |
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| Abstract: | Spironolactone (C24H32O4S) usually crystallizes into an orthorhombic phase, named Form II. Another orthorhombic phase, named Form I, is also known
but seems difficult to obtain. Studies of the kinetics of desolvation of the ethanol solvate at room temperature showed that
these two forms can be obtained through different mechanisms of desolvation. |
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