Adult neurogenesis and specific replacement of interneuron subtypes in the mouse main olfactory bulb |
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| Authors: | Joshua Bagley,Greg LaRocca,Daniel A Jimenez,Nathaniel N Urban |
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| Affiliation: | (1) Department of Biological Science, Carnegie Mellon University, 15213 Pittsburgh, PA, USA;(2) Department of Neuroscience, University of Pittsburgh, 15260 Pittsburgh, PA, USA;(3) Center for the Neural Basis of Cognition, University of Pittsburgh, 15213 Pittsburgh, PA, USA;(4) Center for Neuroscience, University of Pittsburgh, 15213 Pittsburgh, PA, USA;(5) National Institutes of Health/NINDS, 35 Convent Drive, Bldg.35/Rm. #A108, 20892-3703 Bethesda, MD, USA |
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| Abstract: | Background New neurons are generated in the adult brain from stem cells found in the subventricular zone (SVZ). These cells proliferate in the SVZ, generating neuroblasts which then migrate to the main olfactory bulb (MOB), ending their migration in the glomerular layer (GLL) and the granule cell layer (GCL) of the MOB. Neuronal populations in these layers undergo turnover throughout life, but whether all neuronal subtypes found in these areas are replaced and when neurons begin to express subtype-specific markers is not known. |
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