| 反式-4-取代-2-氮杂金刚烷高氯酸盐的合成和立体化学 |
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| 引用本文： | 王广义,Grob,C.A. 反式-4-取代-2-氮杂金刚烷高氯酸盐的合成和立体化学[J]. 化学学报, 1990, 48(4): 382-387 |
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| 作者姓名： | 王广义 Grob C.A |
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| 作者单位： | 巴塞尔大学有机化学研究所 |
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| 摘 要： | 本文报告了若干反式和顺式N-苯甲基-4-取代-2-氮杂金刚烷的合成, 取代基为:H, CH2OH, CH2OAc, CH2OTs, CO2CH3, OH, CONH2, OAc, Cl和CN。反式游离胺用高氯酸处理得N-苯甲基高氯酸盐, 后者催化氢解产生反式4-取代-2-氮杂金刚烷高氯酸盐, 游离胺的立体化学是根据红外和核磁共振光谱方法测定的。
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| 关 键 词： | 铵化合物 催化 红外分光光度法 甲苯 氮杂环化合物 游离基 核磁共振 异构体 立体化学 高氯酸盐 |
Syntheses and stereochemistry of hydroperchlorates of anti-4-substituted 2-azaadamantanes |
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| WANG ANYI,Grob,C.A. Syntheses and stereochemistry of hydroperchlorates of anti-4-substituted 2-azaadamantanes[J]. Acta Chimica Sinica, 1990, 48(4): 382-387 |
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| Authors: | WANG ANYI Grob C.A |
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| Abstract: | N-Benzyl-anti and syn-4-substituted 2-azaadamantanes were prepared starting from adamantane I. Treatment of anti free amines with perchloric acid gave N-benzyl hydroperchlorates, which were hydrogenolyzed to provide the title compounds II (R = H, OH, Cl, cyano, CO2Me, CH2OH, etc.). Stereochem. of the free amines was determine with the help of IR and 1H NMR spectra. |
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| Keywords: | AMMONIUM COMPOUND CATALYSIS INFRARED SPECTROPHOTOMETRY METHYLBENZENE NITROGEN HETEROCYCLICS FREE RADICAL NUCLEAR MAGNETIC RESONANCE ISOMER STEREOCHEMISTRY PERCHLORATE |
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