| 分子内反应与分子内催化I:分子内苯并咪唑基一般碱催化2-(2'-苯并咪唑基)乙酸乙酯及3-(2'-苯并咪唑基)丙酸乙酯水解机理的探讨 |
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| 引用本文： | 夏炽中,夏道宏.分子内反应与分子内催化I:分子内苯并咪唑基一般碱催化2-(2'-苯并咪唑基)乙酸乙酯及3-(2'-苯并咪唑基)丙酸乙酯水解机理的探讨[J].化学学报,1990,48(5):506-510. |
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| 作者姓名： | 夏炽中 夏道宏 |
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| 作者单位： | 山西大学分子科学研究所 |
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| 摘 要： | 本工作测定了2-(2'-苯并咪唑基)乙酸乙酯及3-(2'-苯并咪唑基)丙酸乙酯在不同pH值下的表观水解速率常数在碱性较强的溶液中, 酯的水解反应主要是由氢氧根离子进行分子间特殊碱催化来完成;而在接近中性pH值范围的溶液中, 苯并咪唑基以一般碱催化方式参与了分子内催化酯的水解反应。实验结果与所提出的理论模型较好地吻合。
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| 关 键 词： | 催化 丙酸P 反应机理 乙酸乙酯 乙酯 苯并咪唑 碱 水解反应 |
Intramolecular reaction and intramolecular catalysis I: An approach to the hydrolysis mechanism of intramolecular general base-catalysis by the benzimidazolyl group of ethyl 2-(2'-benzimidazolyl)acetate and ethyl 3-(2'-benzimidazolyl)propionate |
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| XIA CHIZHONG,XIA DAOHONG.Intramolecular reaction and intramolecular catalysis I: An approach to the hydrolysis mechanism of intramolecular general base-catalysis by the benzimidazolyl group of ethyl 2-(2'-benzimidazolyl)acetate and ethyl 3-(2'-benzimidazolyl)propionate[J].Acta Chimica Sinica,1990,48(5):506-510. |
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| Authors: | XIA CHIZHONG XIA DAOHONG |
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| Abstract: | The observed hydrolysis rate constants of the title compounds were determine at different pH values. The experimental results show that in more alkaline solution, the intermol. specific base-catalyzed hydrolysis of these two esters by hydroxide ion predominates, while at pH values close to neutral the intramol. general base-catalyzed hydrolysis of esters by the benzimidazolyl group occurs. |
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| Keywords: | CATALYSIS METHYLACETIC ACID P REACTION MECHANISM ETHYL ACETATE ETHYL ESTER BENZIMIDAZOLE BASE HYROLYSIS |
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