Molecular symmetry and biological activities of new symmetrical tris(2-aminoethyl)amine derivatives |
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Authors: | Mibu Nobuko Yokomizo Kazumi Uchida Wataru Takemura Satoshi Zhou Jianrong Aki Hatsumi Miyata Takeshi Sumoto Kunihiro |
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Affiliation: | Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan. |
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Abstract: | In terms of molecular symmetry and bioactivity, new C3- and CS-symmetrical derivatives based on the tris(2-aminoethyl)amine scaffold were designed and synthesized. The synthesized compounds were evaluated for antiviral activity with herpes simplex virus type 1 (HSV-1) by a plaque reduction assay and for cytotoxic activity with Vero cells. Most of the compounds showed no significant anti-HSV-1 activity, but some of the symmetrical derivatives showed high levels of cytotoxic activitiy. |
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