Synthesis,characterization, and anti-tumor activities of some transition metal(II) complexes with podophyllic acid hydrazide |
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| Authors: | Jian-Qiang Qu Ling Qu Qiu-Hua Yang Liu-Fang Wang |
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| Affiliation: | (1) Department of Chemistry, School of Science, Tianjin University, Tianjin, 300072, China;(2) Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan, 750002, China;(3) State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China |
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| Abstract: | Four transition metal(II) complexes with podophyllic acid hydrazide (HL) were prepared and characterized by elemental analysis, complexometric titration, thermal analysis, conductivity, IR, and 1H NMR. The complexes have the general formula ML2 · nH2O, where M = Zn, Cu, Co, and Ni, n = 2 or 0. Anti-tumor activities of podophyllotoxin, HL, ZnL2 · 2H2O, and NiL2 were tested by both the MTT and the SRB method. The results show that the activities of the complexes against the tumor cells tested are superior to HL and the anti-tumor activity of NiL2 is even similar to that of podophyllotoxin. |
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| Keywords: | transition metal complexes podophyllic acid hydrazide anti-tumor activities |
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