Total synthesis of anibamine, a novel natural product as a chemokine receptor CCR5 antagonist |
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| Authors: | Li Guo Watson Karen Buckheit Robert W Zhang Yan |
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| Affiliation: | Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298-0540, USA. |
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| Abstract: | The total synthesis of anibamine, the first and only natural product known as a chemokine receptor CCR5 antagonist, is reported herein. Anibamine was synthesized from acetylacetone and cyanoacetamide in 10 steps. |
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