Acyclic analogs of pyrimidine nucleosides. Synthesis of 1-(2-hydroxyethoxymethyl)- and 1-(4-hydroxybutyl)-5-amino derivatives of uracil

With the objective of discovering new antiviral agents based on acyclic analogs of pyrimidine nucleosides, we have synthesized 1-(2-hydroxyethoxymethyl)- and 1-(4-hydroxybutyl) derivatives of uracil having various aromatic and heterocyclic amino-containing substituents in the 5 position of the pyrimidine ring.Scientific-Research Institute of Pharmacology, Volgograd Medical Academy, Volgograd 400066, Russia. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 971–978, July, 1998.