Structural development of benzhydrol-type 1'-acetoxychavicol acetate (ACA) analogs as human leukemia cell-growth inhibitors based on quantitative structure-activity relationship (QSAR) analysis |
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Authors: | Misawa Takashi Aoyama Hiroshi Furuyama Taniyuki Dodo Kosuke Sagawa Morihiko Miyachi Hiroyuki Kizaki Masahiro Hashimoto Yuichi |
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Affiliation: | Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan. |
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Abstract: | Benzhydrol-type analogs of 1'-acetoxychavicol acetate (ACA) were developed as inhibitors of human leukemia HL-60 cell growth based on quantitative structure-activity relationship (QSAR) analysis. An analog containing an anthracenyl moiety (8) was a potent inhibitor with the IC(50) value of 0.12 microM. |
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