Aphapolynins A and B, two new limonoids from the fruits of Aphanamixis polystachya |
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| Authors: | Yao ZhangJun-Song Wang Xiao-Bing WangDan-Dan Wei Jian-Guang LuoJun Luo Ming-Hua YangLing-Yi Kong |
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| Affiliation: | Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People’s Republic of China |
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| Abstract: | Two new highly oxidized A,B-seco limonoids, aphapolynins A (1) and B (2), were isolated from the fruits of Aphanamixis polystachya. Their structures were elucidated by spectroscopic analysis, in particular, the absolute configuration of aphapolynin A was determined by a single-crystal X-ray study using a mirror Cu Kα radiation. Aphapolynin A exhibit moderate cytotoxicities when tested against a panel of tumor cell lines. |
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| Keywords: | Aphanamixis polystachya Meliaceae A,B-seco limonoids Cu Kα X-ray crystallography Cytotoxicity |
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