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Total synthesis of ecteinascidin 743 |
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| Authors: | Chen Jinchun Chen Xiaochuan Bois-Choussy Michèle Zhu Jieping |
| Affiliation: | Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France. |
| Abstract: | A convergent total synthesis of ecteinascidin 743 is realized from five building blocks of almost equal size. It takes 23 steps from l-3-hydroxy-4-methoxy-5-methyl phenylalanol (5) with an overall yield of 3%. |
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