99mTc-exorphin C: A new peptide radiopharmaceutical for tumor imaging |
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| Authors: | T. Ertay P. Unak C. Tasci F. Z. Biber F. Zihnioglu H. Durak |
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| Affiliation: | (1) Dokuz Eylül University, Medical School, Dept. of Nuclear Medicine, Inciraltı, Turkey;(2) Ege University, Institute of Nuclear Sciences, Dept. of Nuclear Applications, Bornova, Turkey;(3) Dokuz Eylül University, Medical School, Dept. of Nuclear Medicine, Inciraltı, Turkey;(4) Dokuz Eylül University, Medical School, Dept. of Nuclear Medicine, Inciraltı, Turkey;(5) Ege University, Faculty of Sciences, Department of Biochemistry, Bornova, Izmir, Turkey;(6) Dokuz Eylül University, Medical School, Dept. of Nuclear Medicine, Inciraltı, Turkey |
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| Abstract: | Summary The aim of this study was to label exorphin C with 99mTc and to examine its usefulness as opioid receptor binding radiopharmaceutical in Albino Wistar rats. Exorphin C, which is a peptide with 5 aminoacids, was labeled with 99mTc using glucoheptonate (GH) as a bifunctional chelating agent. Labeling efficiency was higher than 98%. The compound was stable for at least 5 hours at room temperature. Mammary tumor bearing Albino Wistar rats were imaged using gamma-camera. Biodistribution studies were also performed. Results demonstrated that 99mTc-glucoheptonate-exorphin C (99mTc-GE) analogs may be useful as a new class of receptor-binding peptides for the diagnosis and therapy of some cancer diseases related with opioid receptor-expressing tissues. |
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