Synthesis of substituted 2-(2-oxopyrrolidin-1-yl)acetamides |
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Authors: | M. A. Kavina V. V. Sizov I. P. Yakovlev |
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Affiliation: | 1.CHEM Ltd. Scientific and Production Company,Kuz’molovskii, Leningrad oblast,Russia;2.St. Petersburg State Chemical Pharmaceutical Academy,St. Petersburg,Russia |
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Abstract: | The reaction of chloroacetamide with 2 equiv of γ-aminobutyric acid potassium salts provides a convenient method for the synthesis of substituted 4-[(2-amino-2-oxoethyl)amino]butanoic acids. Alkylation products of 2-aminoacetic and 3-aminopropanoic acid with chloroacetamide were isolated. Thermal cyclization of substituted 4-[(2-amino-2-oxoethyl)amino]butanoic acids afforded 2-(2-oxopyrrolidin-1-yl)acetamides. |
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