Synthesis of (2<Emphasis Type="Italic">R</Emphasis>,4<Emphasis Type="Italic">R</Emphasis>)-2-alkyl-3-(2-mercaptobenzoyl)thiazolidine-4-carboxylic acids |
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| Authors: | А Yu Ershov I V Lagoda D G Nasledov M Yu Vasil’eva L Yu Kuleshova L V Pavlova A V Yakimanskii |
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| Institution: | 1.Institute of Macromolecular Compounds,Russian Academy of Sciences,St. Petersburg,Russia;2.R&D Test Center (of Medico-Biological Protection), State R&D Institute of Military Medicine,Russian Ministry of Defense,St. Petersburg,Russia;3.Ryazan Medical University,Ryazan,Russia;4.St. Petersburg State University,St. Petersburg,Russia |
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| Abstract: | Basing on natural amino acid L-cysteine, commercially available aliphatic aldehydes, 2-acetylsulfanylbenzoyl chloride and 2,2′-disulfandiyldibenzoyl dichloride a synthesis was developed of (2R,4R)-2-alkyl-3-(2-mercaptobenzoyl)thiazolidine-4-carboxylic acids, potential antihypertensive compounds, inhibitors of angiotensin transforming enzyme. |
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