Synthesis and anti-influenza activity of 2-cyanoethoxy and 2-(1<Emphasis Type="Italic">H</Emphasis>-tetrazol-5-yl)ethoxy derivatives of dammarane-type triterpenoids |
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Authors: | A D Zorina A S Kaledina I A Motsepuro V V Anokhina S A Marchenko S I Selivanov V V Zarubaev R E Trifonov |
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Institution: | 1.St. Petersburg State University,St. Petersburg,Russia;2.St. Petersburg Pasteur Research Institute of Epidemiology and Microbiology,St. Petersburg,Russia |
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Abstract: | A series of 3-(2-1Н-tetrazol-5-ylethoxy- and 2-1Н-tetrazol-5-ylethoxyimino) derivatives of dammarane triterpenoids was synthesized by azidation of 3-(2-cyanoethoxy- and 2-cyanoethoxyimino)-dammaranes. The anti-influenza activity of the prepared tetrazolyldammaranes and intermediate compounds against influenza virus А H1N1 was tested. A considerable antiviral activity was observed for 20(S)-3-(2-1Н-tetrazol-5-ylethoxyimino)-25,26,27-trinor-20,24-olidedammarane (SI 26). |
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