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Synthesis and anti-influenza activity of 2-cyanoethoxy and 2-(1<Emphasis Type="Italic">H</Emphasis>-tetrazol-5-yl)ethoxy derivatives of dammarane-type triterpenoids
Authors:A D Zorina  A S Kaledina  I A Motsepuro  V V Anokhina  S A Marchenko  S I Selivanov  V V Zarubaev  R E Trifonov
Institution:1.St. Petersburg State University,St. Petersburg,Russia;2.St. Petersburg Pasteur Research Institute of Epidemiology and Microbiology,St. Petersburg,Russia
Abstract:A series of 3-(2-1Н-tetrazol-5-ylethoxy- and 2-1Н-tetrazol-5-ylethoxyimino) derivatives of dammarane triterpenoids was synthesized by azidation of 3-(2-cyanoethoxy- and 2-cyanoethoxyimino)-dammaranes. The anti-influenza activity of the prepared tetrazolyldammaranes and intermediate compounds against influenza virus А H1N1 was tested. A considerable antiviral activity was observed for 20(S)-3-(2-1Н-tetrazol-5-ylethoxyimino)-25,26,27-trinor-20,24-olidedammarane (SI 26).
Keywords:
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