Colorimetric determination of some important hydrazine derivatives |
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| Authors: | Amina M. El-Brashy Fawzia A. Ibrahim Saadia M. El-Ashry |
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| Affiliation: | (1) Department of Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt |
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| Abstract: | A simple and rapid colorimetric method for the determination of isoniazid, isocarboxazid, iproniazid phosphate, phenelzine sulphate and phenylhydrazine hydrochloride is described. The method is based on the formation of ferroin, when the studied drugs react with a mixture of iron (III) and 1,10-phenanthroline, and measurement of the absorbance at 512 nm. The procedure has been successfully applied to the assay of the pharmaceutical preparations of the studied drugs and the results are favorably comparable to the official methods. |
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| Keywords: | isoniazid isocarboxazid iproniazid phenelzine phenylhydrazine pharmaceutical analysis colorimetry 1,10-phenanthroline |
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