Mesoporous silica nanoparticles in an efficient solvent-free transamidation of carboxamides with amines: an exhibition of a green recyclable nanocatalyst
1.Department of Chemistry,Tarbiat Modares University,Tehran,Iran
Abstract:
A protocol is described for an efficient transamidation of amides with amines in the presence of mesoporous silica nanoparticles (MSNs). The latter is used as a green, heterogeneous, and recyclable nanocatalyst, under solvent-free conditions. Following this protocol, a wide range of aromatic, aliphatic, and cyclic/acyclic primary or secondary amines are used in synthesis of a series of amides with good to excellent yields (65–96%). MSNs is characterized by using scanning electron microscopy (SEM), transmission electron microscopy (TEM), small-angle powder X-ray diffraction (XRD), nitrogen adsorption-desorption analysis, and FT-IR spectroscopy. The metal/solvent-free condition, easy work up, high purity of the products, recyclability, and environmentally-friendly nature of the catalyst are the attractive features of this methodology.
Graphical abstract An efficient transamidation of carboxamides was achieved via the use of mesoporous nanoparticles as green nanocatalyst. The metal/solvent-free condition, easy work up, high purity of the products, recyclability, and environmentally-friendly nature of the catalyst are the attractive features of this methodology.