Synthesis and search for compounds with hemostatic activity in the series of 4-(het)aryl-4-oxobut-2-enoic acid derivatives期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Synthesis and search for compounds with hemostatic activity in the series of 4-(het)aryl-4-oxobut-2-enoic acid derivatives

Authors:	N?A?Pulina Email author" target="_blank">V?Yu?Kozhukhar Email author A?S?Kuznetsov A?E?Rubtsov A?V?Starkova

Institution:	1.Perm State Pharmaceutical Academy, the Ministry of Healthcare of the Russian Federation,Perm,Russian Federation;2.Perm State National Research University,Perm,Russian Federation

Abstract:	New 4-aryl-2-(4-arylamino)-1-(piperazin-1-yl)but-2-ene-1,4-diones and 2-{2-(3-R-adamantan-1-yl)-2-oxoethylidene]hydrazinyl}-4-(het)aryl-4-oxobut-2-enoic acids were synthesized and used to obtain water-soluble compounds. Their influence on the blood coagulation system was studied, which revealed compounds with a high hemostatic activity and a low acute toxicity. A relationship between structure and pharmacological effect of the synthesized compounds was established.

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