| (3aS,6aR)-1,3-二苄基-六氢-1H-噻吩并[3,4-d]咪唑-2,4-二酮制备方法的改进 |
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| 引用本文： | 顾立新,王伟,蒋定强,黄忠印,沈润溥.(3aS,6aR)-1,3-二苄基-六氢-1H-噻吩并[3,4-d]咪唑-2,4-二酮制备方法的改进[J].化学研究与应用,2007,19(9):1056-1058,1062. |
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| 作者姓名： | 顾立新 王伟 蒋定强 黄忠印 沈润溥 |
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| 作者单位： | 浙江医药股分有限公司新昌制药厂,浙江,新昌,3125002;绍兴文理学院化学化工学院,浙江,绍兴,312000 |
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| 摘 要： | ( )-生物素,又称维生素H或辅酶R,化学名(3aS,4S,6aR)-六氢-2-氧-噻吩并3,4-d]咪唑-4-戊酸,属于水溶性B族维生素,是整个生物界所必须的。生物素在维持动物正常发育,繁殖及保持皮肤、羽毛和骨骼健康中发挥重要作用。自1949年瑞士Roche公司首次开发化学全合成d-生物素后,经过几十
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| 关 键 词： | (+)-生物素 (3aS 6aR)-1 3-二苄基-六氢-1H-噻吩并[3 4-d]咪唑-2 4-二酮 3-二苄基-六氢-1H-呋喃并[3 硫代乙酰胺 五硫化二磷 乙酰胺 制备 |
| 文章编号： | 1004-1656（2007）09-1056 |
| 收稿时间： | 2007-03-20 |
| 修稿时间： | 2007-03-202007-06-18 |
Improved method for the synthesis of (3aS,6aR)-1,3-dipenzyl-hexahydro-1H-thieno[3,4-d]imidazole-2,4-dione |
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| GU Li-xin,WANG Wei,JIANG Ding-qiang,HUANG Zhong-yin,SHEN Run-pu.Improved method for the synthesis of (3aS,6aR)-1,3-dipenzyl-hexahydro-1H-thieno[3,4-d]imidazole-2,4-dione[J].Chemical Research and Application,2007,19(9):1056-1058,1062. |
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| Authors: | GU Li-xin WANG Wei JIANG Ding-qiang HUANG Zhong-yin SHEN Run-pu |
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| Institution: | 1.Zhejiang Medicine Co.Ltd.,Xinchang Pharmaceutical Factory,Xinchang 312500,China; 2.Shaoxing University,Shaoxing 312000,China |
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| Abstract: | Thioacetamide is made from phosphorus pentasulfide and acetamide,which react with(3aS,6aR)-1,3-dibenzyl-hexahydro-1H-furo3,4-d]imidazole-2,4-dione as sulfo-reagent to prepare(3aS,6aR)-1,3-dibenzyl-hexahydro-1H-thienoimidazole-2,4-dione in the same system,yield is 91.9%,material get easily and cost reduce by this method,which is suitable for industrial process. |
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| Keywords: | ( )-Biotin (3aS 6aR)-1 3-dibenzyl-hexahydro-1H-thienoimidazole-2 4-dione (3aS 6aR)-1 3-dibenzyl-hexahydro-1H-furoimidazole-2 4-dione thioacetamide phosphorus pentasulfide acetamide prepare |
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