| 拉曼光谱技术在恶性骨肿瘤患者红细胞中的研究应用 |
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| 引用本文： | 李和仙,刘伟,赵元黎,王丽君,张彦陟.拉曼光谱技术在恶性骨肿瘤患者红细胞中的研究应用[J].光学与光电技术,2011,9(2):15-18,45. |
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| 作者姓名： | 李和仙 刘伟 赵元黎 王丽君 张彦陟 |
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| 作者单位： | 1. 闽南理工学院,福建泉州,362700
2. 郑州大学物理工程学院材料物理教育部重点实验室,河南郑州,450052 |
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| 摘 要： | 对单晶态血红蛋白和红细胞的拉曼光谱进行了研究.发现在600～1 750 cm-1的范围内,红细胞与单晶态血红蛋白的拉曼谱图极其相似,只有小量的峰移和加宽.实验结果表明可以通过分析红细胞的拉曼谱图中与heme相关的特征峰来研究红细胞内血红蛋白的结构及功能.对正常人和恶性骨肿瘤患者红细胞的拉曼光谱进行了分析,发现恶性骨肿瘤...
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| 关 键 词： | 红细胞 血红蛋白 恶性骨肿瘤 拉曼光谱 |
Raman Spectra of Red-Cell from the Malignant Tumors |
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| LI He-xian,LIU Wei,ZHAO Yuan-li,WANG Li-jun,ZHANG Yan-zhi.Raman Spectra of Red-Cell from the Malignant Tumors[J].optics&optoelectronic technology,2011,9(2):15-18,45. |
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| Authors: | LI He-xian LIU Wei ZHAO Yuan-li WANG Li-jun ZHANG Yan-zhi |
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| Institution: | 1 (1 Minnan University of Science and Technology.Quanzhou 362700.China; 2 Physical Engineering College of Zhengzhou University,Key Laboratory of Materials Physics of State Education Commission, Zhengzhou University,Zhengzhou 450052,China) |
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| Abstract: | The UV spectra and Raman spectra of Hb（Hemoglobin） in crystalline state and in red cells arc obtained.From 600 to 1 750 cm-1,the Raman spectra of Hb in red cells are similar to those in crystalline state except little Shifts and broadening. The results show that we can get the information of the structure and function of Hb by studying the spectra of heme in red cells.The raman spectra of red-cell from the normal blood and the malignant osteoma blood arc also obtained.The ratio of comparatively intensity of lines in red-cell between the malignant osteoma and the normal minish in 1 505 cm1,1 228 cm1,1 087 cm-1,1 001 cm1 and 747 cm-1,which show the contents of heme、phenylalanine and deoxyribose in red-cell reduces. According to the statistic analysis,the changes of I1586、1228、I1586、1001 and I158、1169 can provide a method for diagnosing malignant osteoma. |
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| Keywords: | red-cell HB malignant osteoma Raman spectra |
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