Asymmetric, organocatalytic, three-step synthesis of gamma-hydroxy-(E)-alpha,beta-unsaturated sulfones and esters |
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| Authors: | Petersen Kimberly S Posner Gary H |
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| Affiliation: | Department of Chemistry, Johns Hopkins University, 3400 Charles Street, Baltimore, Maryland 21218, USA. |
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| Abstract: | Efficient and enantiocontrolled synthesis of gamma-hydroxy-alpha,beta-unsaturated sulfones and esters are reported through the reaction of enantioenriched alpha-selenyl aldehydes with EWG-stabilized carbanions and then a one-pot selenide oxidation, in situ epoxide formation, and final in situ epoxide opening. |
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