Highly enantioselective hydroformylation of aryl alkenes with diazaphospholane ligands |
| |
Authors: | Watkins Avery L Hashiguchi Brian G Landis Clark R |
| |
Institution: | Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA. |
| |
Abstract: | Asymmetric, rhodium-catalyzed hydroformylation of terminal and internal aryl alkenes with diazaphospholane ligands is reported. Under partially optimized reaction conditions, high enantioselectivity (>90% ee) and regioselectivities (up to 65:1 alpha:beta) are obtained for most substrates. For terminal alkenes, both enantioselectivity and regioselectivity are proportional to the carbon monoxide partial pressure, but independent of hydrogen pressure. Hydroformylation of para-substituted styrene derivatives gives the highest regioselectivity for substrates bearing electron-withdrawing substituents. A Hammett analysis produces a positive linear correlation for regioselectivity. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|