Hydrogenation of hindered ketones catalyzed by a silica-supported compact phosphine-Rh system |
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| Authors: | Kawamorita Soichiro Hamasaka Go Ohmiya Hirohisa Hara Kenji Fukuoka Atsushi Sawamura Masaya |
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| Institution: | Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan. |
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| Abstract: | A heterogeneous mono(phosphine)-Rh catalyst system silica-SMAP-Rh(OMe)(cod), where silica-SMAP stands for a caged, compact trialkylphosphine (SMAP) supported on silica gel, showed broad applicability toward the hydrogenation of hindered ketones. Doubly alpha-branched ketones such as diisopropyl ketone was hydrogenated under nearly atmospheric conditions. Di-tert-butyl ketone could be hydrogenated under more forcing conditions. |
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