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Synchrotron SAX and WAX diffraction study of a hydrated very long-chain, dendritic amphiphile + DPPC mixture |
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| Authors: | Karlovská Janka Williams André A Macri Richard V Gandour Richard D Funari Sérgio S Uhríková Daniela Balgavý Pavol |
| Institution: | aDepartment of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32 Bratislava, Slovakia bDepartment of Chemistry, MC 0212, Virginia Tech, Blacksburg, VA 24061, USA cHASYLAB DESY, D-22603 Hamburg, Germany |
| Abstract: | The tri-headed anionic dendritic amphiphile, 4-(2-carboxyethyl)-4-(icosyloxycarbonyl)amino]heptanedioic acid (3CCb20), forms mixed aggregates with dipalmitoylphosphatidylcholine (DPPC) in excess water at 3CCb20:DPPC = 0.91:1 molar ratio. On heating, these mixed aggregates transform into fluid bilayers stacked in the liquid crystalline lamellar L phase at about 40 °C. This phase transition and the microstructure of 3CCb20 + DPPC aggregates were studied with small- and wide-angle synchrotron X-ray diffraction. The ability of 3CCb20 to solubilize solidlike lipid bilayers could contribute to the antimicrobial activities of 3CCb20, including its anti-HIV activity. |
| Keywords: | Amphiphiles DPPC Mixed aggregates Bilayers X-ray diffraction Phase transition |
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