Palladium-Catalyzed Carbonylative Four-Component Synthesis of β-Perfluoroalkyl Amides |
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Authors: | Dr Youcan Zhang Hui-Qing Geng Prof?Dr Xiao-Feng Wu |
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Institution: | 1. Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, Liaoning, P. R. China;2. Leibniz-Institut für Katalyse e.V., Albert-Einstein-Strasse 29a, 18059 Rostock, Germany |
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Abstract: | Transition-metal-catalyzed multicomponent carbonylation is one of the most efficient strategies to construct carbonyl-containing compounds. Herein, a palladium-catalyzed four-component perfluoroalkylation/aminocarbonylation of unactivated alkenes with perfluoroalkyl halides, and amines was developed. A wide range of substrates, including anilines, alkylamines, sulfonamides, and hydrazines are all suitable reaction partners for this catalyst system, resulting in various β-perfluoroalkyl amides with good functional-group tolerance and excellent chemoselectivity. Furthermore, not only alkyl olefins, but also aliphatic alkynes, and even alkyl allenes can all be employed. Notably, several medical and bioactive related molecules are compatible here as well. |
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Keywords: | aminocarbonylation β-perfluoroalkyl amides multicomponent reaction palladium catalyst perfluoroalkylation |
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