Chlorophyll a π-Cation Radical as Redox Mediator in Superoxide Dismutase (SOD) Mimetics |
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| Authors: | Dr Łukasz Orzeł Dr Dorota Rutkowska-Zbik Prof Rudi van Eldik Prof Leszek Fiedor Prof Grażyna Stochel |
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| Institution: | 1. Faculty of Chemistry, Jagiellonian University, Kraków, Poland;2. Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Kraków, Poland;3. Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland |
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| Abstract: | The extensive speciation of copper(II) chloride in organic solvents varies with concentration, temperature, pressure and oxygen content, providing the ability to switch between different chlorophyll transmetalation pathways. We found that one of them is exceptionally suitable for the formation and stabilisation of the chlorophyll π-cation radical. This is due to unique redox cycling, which is coupled to the generation and transformation of various reactive oxygen species. In the presence of a proton donor, our system shows behavior which resembles that of superoxide dismutase (SOD). Regardless of light, chlorophyll acts as an electron transfer mediator. |
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| Keywords: | chlorophyll a π-cation radical reactive oxygen species redox cycling SOD mimicking |
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