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Aromatic Trifluoromethylselenolation via Pd-catalyzed C?H functionalization |
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| Authors: | Kevin Grollier Emmanuel Chefdeville Dr Erwann Jeanneau Dr Thierry Billard |
| Institution: | 1. Institute of Chemistry and Biochemistry (ICBMS – UMR CNRS 5246), Univ Lyon, CNRS, Université Lyon 1, 43 Bd du 11 novembre 1918, 69622 Lyon, France;2. NMR Centre Univ Lyon, Université Lyon 1, CNRS, 43 Bd du 11 novembre 1918, 69622 Lyon, France;3. Centre de Diffractométrie Henri Longchambon, Univ Lyon, Université Lyon 1, 5 rue de la Doua, 69100 Villeurbanne, France |
| Abstract: | The synthesis of trifluoromethylselenolated aromatic molecules via an auxiliary-assisted, palladium catalyzed, C?H bonds functionalization with trifluoromethyl tolueneselenosulfonate as reagent is described. The mono- or bis-products can be preferentially formed. Some mechanistic investigations were realized to better understand the reaction. This methodology was also extended to fluoroalkylselenyl groups. |
| Keywords: | C?H functionalization fluorine selenium trifluoromethylselenolation trifluoromethylselenosulfonate |