|
|||||
|
|
MicroRNA-Triggered Nanozymes Cascade Reaction for Tumor-Specific Chemodynamic Therapy |
|
| Authors: | Hao Liu Yawen You Yanjuan Sang Dr. Fang Pu Prof. Jinsong Ren Prof. Xiaogang Qu |
| Affiliation: | 1. Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022 P. R. China School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026 P. R. China;2. Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022 P. R. China |
| Abstract: | Off-target toxicity and insufficient hydroxyl radicals (.OH) generation limit the further clinical application of nanozymes in chemodynamic therapy (CDT). Herein, we designed and constructed a microRNA-triggered nanozyme cascade platform for enhanced tumor-specific chemodynamic therapy. The nanozyme-based cascade reaction could be triggered successfully by the high expression of microRNA in cancer cells to generate more .OH, thus exhibiting excellent tumor-specific therapeutic performance. Our work provides a new dimension for tumor-specific chemodynamic therapy. |
| Keywords: | cascade reaction chemodynamic therapy miRNA-21 nanozyme tumor specificity |