Rigid and Compact Binuclear Bis-hydrated Gd-complexes as High Relaxivity MRI Agents |
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Authors: | Dr. Loredana Leone Luca Guarnieri Dr. Jonathan Martinelli Prof. Massimo Sisti Prof. Andrea Penoni Prof. Mauro Botta Prof. Lorenzo Tei |
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Affiliation: | 1. Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, viale T. Michel 11, 50121 Alessandria, Italy;2. Dipartimento di Scienza e Alta Tecnologia, Università dell'Insubria, Via Valleggio 11, Como, 22100 Italy |
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Abstract: | The first binuclear Gd-complex of the 12-membered pyridine-based polyaminocarboxylate macrocyclic ligand PCTA was synthesized by C−C connection of the pyridine units through two different synthetic procedures. A dimeric AAZTA-ligand was also synthesized with the aim to compare the relaxometric results or the two ditopic Gd-complexes. Thus, the 1H relaxometric study on [Gd2PCTA2(H2O)4] and on [Gd2AAZTA2(H2O)4]2− highlighted the remarkable rigidity and compactness of the two binuclear complexes, which results in molar relaxivities (per Gd), at 1.5 T and 298 K of ca. 12–12.6 mM−1 s−1 with an increase of ca. 80 % at 1.5 T and 298 K (+70 % at 310 K) with respect to the corresponding mononuclear complexes. |
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Keywords: | binuclear complexes contrast agents gadolinium macrocycles relaxometry |
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