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A Versatile Compact Parahydrogen Membrane Reactor |
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| Authors: | Patrick M TomHon Dr Suyong Han Dr Sören Lehmkuhl Prof Stephan Appelt Prof Eduard Y Chekmenev Prof Milad Abolhasani Prof Thomas Theis |
| Institution: | 1. Department of Chemistry, North Carolina State University, Raleigh, NC, 27695 USA;2. Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, 27606 USA
These authors contributed equally.;3. Central Institute for Engineering, Electronics and Analytics – Electronic Systems (ZEA-2), Forschungszentrum Jülich GmbH, 52425 Jülich, Germany Institut für Technische Chemie und Makromolekulare Chemie (ITMC), RWTH Aachen University, 52056 Aachen, Germany;4. Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, MI, 48202 USA Russian Academy of Sciences, Leninskiy Prospekt 14, 119991 Moscow, Russia;5. Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, 27606 USA |
| Abstract: | We introduce a Spin Transfer Automated Reactor (STAR) that produces continuous parahydrogen induced polarization (PHIP), which is stable for hours to days. We use the PHIP variant called signal amplification by reversible exchange (SABRE), which is particularly well suited to produce continuous hyperpolarization. The STAR is operated in conjunction with benchtop (1.1 T) and high field (9.4 T) NMR magnets, highlighting the versatility of this system to operate with any NMR or MRI system. The STAR uses semipermeable membranes to efficiently deliver parahydrogen into solutions at nano to milli Tesla fields, which enables 1H, 13C, and 15N hyperpolarization on a large range of substrates including drugs and metabolites. The unique features of the STAR are leveraged for important applications, including continuous hyperpolarization of metabolites, desirable for examining steady-state metabolism in vivo, as well as for continuous RASER signals suitable for the investigation of new physics. |
| Keywords: | hyperpolarization parahydrogen NMR fluidics RASER |