Recognition of homo-polynucleotides containing adenine by a phenanthridinium bis-uracil conjugate in aqueous media |
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| Authors: | Tumir Lidija-Marija Piantanida Ivo Juranović Iva Meić Zlatko Tomić Sanja Zinić Mladen |
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| Affiliation: | Laboratory of Supramolecular and Nucleoside Chemistry, Department of Chemistry and Biochemistry, Ruder Boskovi? Institute, HR 10002 Zagreb, P.O.B. 180, Croatia. |
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| Abstract: | Among novel bis-nucleobase-phenanthridinium conjugates bis-uracil analogue stabilized significantly more effective poly-dA-poly-dT and poly-AH(+)-poly-AH(+) than adenine analogue and reference compound . For the alternating poly-dAdT-poly-dAdT however, the binding preference is lost, pointing to the importance of specific interactions of uracils of with homopolynucleotides containing consecutive adenines. |
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