Synthesis of trifluoromethyl-substituted cyclopropanes via sequential Kharasch-dehalogenation reactions |
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| Authors: | Risse Julie Fernández-Zúmel Mariano A Cudré Yanouk Severin Kay |
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| Institution: | Institut des Sciences et Ingénieries Chimiques, école Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. |
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| Abstract: | A two-step process for the synthesis of trifluoromethyl-substituted cyclopropanes is described. Halothane, an anesthetic agent, is added to olefins in a ruthenium-catalyzed Kharasch reaction. The resulting 1,3-dihalides are converted into cyclopropanes by dehalogenation with magnesium. This procedure represents an alternative to metal-catalyzed cyclopropanations involving trifluoromethyl diazomethane. |
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