Hydrogel design strategies for drug delivery |
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| Affiliation: | 1. Department of Chemical and Biomolecular Engineering, University of California Los Angeles, 420 Westwood Plaza, Los Angeles, CA 90095, United States;2. Department of Chemical and Biomolecular Engineering, Bioengineering, and Dermatology, School of Medicine, University of California Los Angeles, 420 Westwood Plaza, Los Angeles, CA 90095, United States;1. Frontier Institute of Science and Technology, State Key Laboratory for Mechanical Behavior of Materials, Xi''an Jiaotong University, Xi''an 710049, PR China;2. Henan Provincial People''s hospital, Zhengzhou University People''s hospital, Number 7 Weiwu road, Zhengzhou 450003, PR China;3. Department of Orthopaedics, The First Affiliated Hospital, College of Medicine, Xi''an Jiaotong University, Xi''an 710061, PR China;4. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi''an Jiaotong University, Xi''an 710049, PR China;1. Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Science, Kerman, Iran;2. Department of Hematology and Laboratory Sciences, Faculty of Allied Medical Sciences, Kerman University of Medical Sciences, Kerman, Iran;3. Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Science, Kerman, Iran;4. Environmental Technology Division, School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia;5. Institute of Nano Science and Nano Technology, University of Kashan, P.O. Box 87317-51167, Kashan, Iran |
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| Abstract: | Hydrogels are water-swollen three-dimensional networks made of polymers, proteins, small molecules or colloids. They constitute a versatile platform for drug delivery because of their capacity to encapsulate and protect drugs and provide sustained and/or remotely programmable spatial and temporal release and have thus generated a substantial amount of research for the delivery of either small active compounds or biopharmaceuticals. This article discusses the features that make hydrogels attractive as matrices for delivery and reviews a range of designs, focussing on studies from recent years, in particular: ‘smart’ hydrogels (responding to temperature, light, magnetic fields, ultrasounds or combined stimuli); recent technologies: 3D printing and microneedles; and closes by discussing polymer-free drug delivery systems: peptides, small molecules and colloids. |
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| Keywords: | Hydrogels Drug delivery Supramolecular gels Controlled release Smart gels Microneedles 3D printing |
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