Silk Fibroin Combined with Electrospinning as a Promising Strategy for Tissue Regeneration |
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Authors: | Kai Chen Yonghui Li Youbin Li Weisan Pan Guoxin Tan |
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Affiliation: | 1. Hainan Provincial Key Laboratory of R&D on Tropical Herbs, Haikou Key Laboratory of Li Nationality Medicine, School of Pharmacy, Hainan Medical University, Haikou, 571199 P. R. China;2. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016 P. R. China;3. Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmacy, Hainan University, Haikou, 570228 P. R. China |
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Abstract: | The development of tissue engineering scaffolds is of great significance for the repair and regeneration of damaged tissues and organs. Silk fibroin (SF) is a natural protein polymer with good biocompatibility, biodegradability, excellent physical and mechanical properties and processability, making it an ideal universal tissue engineering scaffold material. Nanofibers prepared by electrospinning have attracted extensive attention in the field of tissue engineering due to their excellent mechanical properties, high specific surface area, and similar morphology as to extracellular matrix (ECM). The combination of silk fibroin and electrospinning is a promising strategy for the preparation of tissue engineering scaffolds. In this review, the research progress of electrospun silk fibroin nanofibers in the regeneration of skin, vascular, bone, neural, tendons, cardiac, periodontal, ocular and other tissues is discussed in detail. |
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Keywords: | electrospinning regeneration silk fibroin tissue engineered |
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