Retention parameters of aromatic hydrocarbons with mono-substituted polar groups in binary RP-HPLC systems |
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Authors: | T H Dzido H Engelhardt |
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Institution: | (1) Department of Inorganic and Analytical Chemistry, Medical Academy, Staszica 6, 20-081 Lublin, Poland;(2) Department of Applied Physical Chemistry, University of Saarland, 66041 Saarbrücken, Germany |
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Abstract: | Summary Capacity factor (k′) values of aromatic hydrocarbons with mono-substituted polar-groups are correlated for reversed-phase
systems involving stationary phases with C18 or C4 ligands chemically bonded to silica and a binary aqueous eluent containing modifiers: methanol, acetonitrile, tetrahydrofuran,
isopropanol, dioxane or dimethoxyethane. The relative retention variations of the solutes are interpreted with special consideration
of their interactions with non-polar stationary phases and the molecular structure of the modifiers and solutes. Rules for
retention and selectivity optimisation in RP-HPLC systems are given. |
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Keywords: | Column liquid chromatography Reversed-phase systems Binary eluents Mono-substituted aromatics Retention and selectivity |
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