Synthesis and Antiradical Activity of 5-Acetyl-2-alkylthio-4-aryl-6-methyl-1,4-dihydropyridine-3-carboxylic Acid Nitriles |
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Authors: | D. Tirzite A. Krauze A. Zubareva G. Tirzitis G. Duburs |
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Affiliation: | (1) Latvian Institute of Organic Synthesis, Riga, LV-1006 |
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Abstract: | The alkylation of 3-cyano-1,4-dihydropyridine-2(3H)-thiones or the condensation of an aromatic aldehyde, cyanothioacetamide, acetylacetone, and methyl iodide in the presence of piperidine has given a series of novel 5-acetyl-2-alkylthio-4-aryl-6-methyl-1,4-dihydropyridine-3-carboxylic acid nitriles. A compound was obtained from 3,5-di(tert-butyl)-4-hydroxybenzaldehyde in the molecule of which were combined the active part of the antioxidant ionol and a 1,4-dihydropyridine ring. It was found that, among the compounds synthesized, the highest antiradical activity occurred in a compound having two hydroxyl groups in the 4-phenyl substituent. |
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Keywords: | 1,4-dihydropyridines 1,1-diphenyl-2-picrylhydrazyl radical cation trolox antiradical activity |
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