Gold-catalyzed hydrosilyloxylation driving tandem aldol and mannich reactions |
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Authors: | Dongjin Kang Sangjune Park Taekyu Ryu Phil Ho Lee |
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Affiliation: | Department of Chemistry, Kangwon National University , Chuncheon 200-701, Republic of Korea. |
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Abstract: | The chemoselective formation of an enolate from alkyne in the presence of a carbonyl and imine group was realized, which constructed a variety of structural motifs under exceedingly mild reaction conditions in a tandem process. Reaction driving tandem hydrosilyloxylation/aldol reactions was achieved through the formation of enol silyl ethers catalytically generated in situ from readily available alkynes. These reactions were expanded to obtain β-amino enol silyl ethers in good yields via the tandem hydrosilyloxylation/isomerization/Mannich reaction. |
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