Spirastrellolide B: Construction of the C(26)-C(40) Northern Hemisphere and a Related [5,5,7]-Bis-spiroketal Analogue |
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Authors: | Xiaozhao Wang Thomas J Paxton Ningkun Li Amos B Smith |
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Institution: | Department of Chemistry, University of Pennsylvania , Philadelphia, Pennsylvania 19104, United States. |
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Abstract: | Differential synthetic access to an advanced C26-C40 northern hemisphere fragment of spirastrellolide B and to a related 5,5,7]-bis-spiroketal analogue from a common intermediate has been achieved. Central to this venture is the regiocontrolled functionalization of a C(31-32) alkyne, exploiting different transition metal catalysts (cf. Pt(II) and Au(I)). |
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