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Multipurpose biological reference materials
Authors:Venkatesh Iyengar  Wayne R Wolf and James Tanner
Institution:(1) National Institute of Standards and Technology (Formerly NBS), 20899 Gaithersburg, MD, USA;(2) United States Department of Agriculture, 20705 Beltsville, MD, USA;(3) United States Food and Drug Administration, 20234 Washington, DC, USA
Abstract:Summary Reference materials to meet multipurpose needs for analysis of both inorganic and organic constituents in biological investigations are not readily available. A human total diet material is being investigated as a reference material for a wide variety of constituents of interest to human nutrition and health. This material shows a stable assay value for the natural levels of a number of vitamins following freeze-drying or radiation sterilization. This is an important feature in producing materials for long term stability as a Reference Material for natural levels of these constituents. An exception is an increase of 34% in assay value of folic acid upon freeze-drying and an 85% increase upon freezedrying followed by radiation sterilization.
Vielseitig verwendbare biologische Referenzmaterialien
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