| 手性Salen(Co)(OAc)催化胺解动力学拆分外消旋末端的环氧化物 |
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| 引用本文： | 王朝阳,宋光伟,朱锦桃.手性Salen(Co)(OAc)催化胺解动力学拆分外消旋末端的环氧化物[J].有机化学,2009,29(7):1142-1146. |
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| 作者姓名： | 王朝阳 宋光伟 朱锦桃 |
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| 作者单位： | 浙江理工大学化学系,杭州,310018 |
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| 摘 要： | 报道了以邻苯二甲酰亚胺作亲核试剂, 在手性催化剂salen(Co)(OAc)作用下动力学拆分外消旋末端环氧化物, 得到较高光学活性的末端环氧化物, 同时也得到了中等光学活性的N-保护的1,2-胺醇化合物. 该拆分反应所用催化剂易得, 且原料价廉, 反应无需惰性气体保护.
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| 关 键 词： | 动力学拆分 环氧化合物 手性salen(Co)(OAc) 邻苯二甲酰亚胺 |
| 收稿时间： | 2008-9-13 |
| 修稿时间： | 2008-11-29 |
Efficient Kinetic Resolution of Terminal Epoxides with Phthalimide Using Chiral Salen(Co)(OAc) |
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| Wang, Chaoyang,Song, Guangwei,Zhu, Jintao.Efficient Kinetic Resolution of Terminal Epoxides with Phthalimide Using Chiral Salen(Co)(OAc)[J].Chinese Journal of Organic Chemistry,2009,29(7):1142-1146. |
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| Authors: | Wang Chaoyang Song Guangwei Zhu Jintao |
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| Institution: | (Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018) |
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| Abstract: | The example of enantioselective kinetic resolution (KR) of racemic terminal epoxides using phthalimide as the nucleophile catalyzed by chiral salen(Co)(OAc) is described. The process afforded enantiopure epoxides and enantioenrich N-protected 1,2-amino alcohol in moderate ee value. Using an easily accessible catalyst and inexpensive staring materials, the reaction was conveniently carried out without protected atmosphere. |
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| Keywords: | kinetic resolution terminal epoxide chiral salen(Co)(OAc) phthalimide |
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