Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA |
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| Authors: | Braasch D A Corey D R |
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| Affiliation: | Departments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9041, USA. |
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| Abstract: | Locked nucleic acid is an RNA derivative in which the ribose ring is constrained by a methylene linkage between the 2'-oxygen and the 4'-carbon. This conformation restriction increases binding affinity for complementarity sequences and provides an exciting new chemical approach for the control of gene expression and optimization of microarrays. |
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