Bisucaberin biosynthesis: an adenylating domain of the BibC multi-enzyme catalyzes cyclodimerization of N-hydroxy-N-succinylcadaverine |
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| Authors: | Kadi Nadia Song Lijiang Challis Gregory L |
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| Institution: | Department of Chemistry, University of Warwick, Coventry, UKCV4 7AL. |
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| Abstract: | The bisucaberin biosynthetic gene cluster has been identified in Vibrio salmonicida and a domain from within the BibC multienzyme encoded by the cluster has been shown to catalyse ATP-dependent dimerisation and macrocyclisation of N-hydroxy-N-succinylcadaverine to form bisucaberin. |
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