Photoactivatable HNO-releasing compounds using the retro-Diels-Alder reaction |
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| Authors: | Adachi Yusuke Nakagawa Hidehiko Matsuo Kazuya Suzuki Takayoshi Miyata Naoki |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8673, Japan. |
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| Abstract: | We synthesized hetero-Diels-Alder cycloadducts from acyl nitroso derivatives and 9,10-dimethylanthracene, to be photo-inducible HNO-releasing agents and found that introduction of conjugated nitroaromatic groups effectively enhanced the responsiveness of HNO release to UV-A irradiation; we confirmed photoinduced HNO formation by EPR and GCMS analysis. |
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