Detoxification system for inorganic arsenic: transformation of As2O3 into TMAO by vitamin B12 derivatives and conversion of TMAO into arsenobetaine |
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Authors: | Nakamura Koichiro Hisaeda Yoshio Pan Ling Yamauchi Hiroshi |
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Institution: | R & D Department, Nippon Sheet Glass Co., Ltd., Chitose-cho 2, Yokkaichi, Mie, Japan. KoichiroNakamura@mail.nsg.co.jp |
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Abstract: | A new two-step synthetic pathway developed for the transformation of arsenic trioxide iAs(III); As(2)O(3)] into arsenobetaine (AB; Me(3)As(+)CH(2)CO(2)(-)) involves treatment of iAs(III) with native B(12) or biomimetic B(12) in the presence of glutathione (GSH) to give TMAO with a high selectivity and a high conversion rate; subsequent treatment of TMAO with iodoacetic acid in the presence of GSH gives arsenobetaine. |
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