Spectroscopic analysis of bladder cancer tissues using Fourier transform infrared spectroscopy |
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Authors: | Nafie A Al-Muslet Essam E Ali |
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Institution: | 1.Institute of Laser,Sudan University of Science and Technology,Khartoum,Republic of Sudan;2.College of Science and Technology,Shendi University,Shendi,Republic of Sudan |
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Abstract: | Bladder cancer is one of the most common cancers in Africa. It takes several days to reach a diagnosis using histological
examinations of specimens obtained by endoscope, which increases the medical expense. Recently, spectroscopic analysis of
bladder cancer tissues has received considerable attention as a diagnosis technique due to its sensitivity to biochemical
variations in the samples. This study investigated the use of Fourier transform infrared (FTIR) spectroscopy to analyze a
number of bladder cancer tissues. Twenty-two samples were collected from 11 patients diagnosed with bladder cancer from different
hospitals without any pretreatment. From each patient two samples were collected, one normal and another cancerous. FTIR spectrometer
was used to differentiate between normal and cancerous bladder tissues via changes in spectra of these samples. The investigations
detected obvious changes in the bands of proteins (1650, 1550 cm–1), lipids (2925, 2850 cm–1), and nucleic acid (1080, 1236 cm–1). The results show that FTIR spectroscopy is promising as a rapid, accurate, nondestructive, and easy to use alternative
method for identification and diagnosis of bladder cancer tissues. |
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