An efficient route for the synthesis of a new class of pyrido[2,3-d]pyrimidine derivatives |
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| Authors: | Tu Shujiang Zhang Junyong Jia Runhong Jiang Bo Zhang Yan Jiang Hong |
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| Affiliation: | Department of Chemistry, Xuzhou Normal University, Key Laboratory of Biotechnology for Medicinal Plant Xuzhou, Jiangsu, 211116, P.R. China. laotu@xznu.edu.cn |
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| Abstract: | A new reaction of 4-arylidene-3-methylisoxazol-5(4H)-one or 4-arylidene-2-phenyloxazol-5(4H)-one with 2,6-diaminopyrimidin-4(3H)-one is described and a number of new pyrido[2,3-d]pyrimidine-4,7-dione derivatives are synthesized. This protocol has the advantages of good yields, broad substrate scope and simple work-up. |
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