A new water-soluble near-neutral ratiometric fluorescent pH indicator |
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| Authors: | Yao Sheng Schafer-Hales Katherine J Belfield Kevin D |
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| Institution: | Department of Chemistry and CREOL, College of Optics and Photonics, University of Central Florida, PO Box 162366, Orlando, Florida 32816-2366, USA. |
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| Abstract: | Donor-pi-acceptor fluorene derivative 1c is a near-neutral pH indicator whose pKa of approximately 7.0 was determined by both absorption and fluorescence methods. 1c satisfies important criteria for a sensitive ratiomeric fluorescent pH indicator with a distinctive isoemissive point, good dispersion in cell cytosol, and low cytotoxicity. Furthermore, its 2PA cross section of 100 GM in its neutral form suggests its potential in two-photon fluorescence imaging applications. |
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