|
|||||
|
|
Reaction of 1,2-trans-glycosyl acetates with phosphorus pentachloride: new efficient approach to 1,2-trans-glycosyl chlorides |
|
| Authors: | Farid M Ibatullin Stanislav I Selivanov |
| Affiliation: | aBiophysics Division, Petersburg Nuclear Physics Institute, Gatchina, 188300, Russia bChemical Department, Petersburg State University, St. Petersburg, Russia |
| Abstract: | Reaction of phosphorus pentachloride with 1,2-trans-glycosyl esters is described. The reaction mechanism presumably involves formation of a tetrachlorophosphonium ion as one of the key reactive intermediates, which can be induced either by Lewis acids or by using acetonitrile as the reaction solvent. Two novel, efficient methods for the synthesis of the thermodynamically unstable glycosyl chlorides were developed based on this reaction. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |