Isolation and structures of biselyngbyasides B,C, and D from the marine cyanobacterium Lyngbya sp., and the biological activities of biselyngbyasides |
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| Authors: | Maho Morita Osamu Ohno Toshiaki Teruya Takao Yamori Toshiyasu Inuzuka Kiyotake Suenaga |
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| Affiliation: | 1. Department of Chemistry, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan;2. Faculty of Education, University of Ryukyus, 1 Senbaru, Nishihara, Okinawa 901-0213, Japan;3. Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan;4. Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan |
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| Abstract: | Bioassay-guided fractionation of the marine cyanobacterium Lyngbya sp. led to the isolation of biselyngbyasides B (3), C (4), and D (5), novel analogs of biselyngbyaside (1) and biselyngbyolide A (2). The gross structures of 3–5 were determined by NMR spectral analyses, and their stereochemistries were established based on NOESY spectra and CD data. Biselyngbyasides (1–3) showed growth-inhibitory activity and apoptosis-inducing activity against both HeLa S3 cells and HL60 cells. The fura-2 method revealed that biselyngbyasides (1–3) increased the cytosolic Ca2+ concentration in HeLa S3 cells. |
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