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Facile approach to diverse 3-acylated indolizines via a sequential Sonogashira coupling/iodocyclization process
Authors:Youngeun Jung  Ikyon Kim
Institution:College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 162-1 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea
Abstract:Successful implementation of a sequential Pd-catalyzed Sonogashira cross-coupling/iodine-promoted 5-exo-dig cyclization procedure with pyridines bearing a terminal alkyne moiety provided direct and straightforward access to a diverse array of 3-acylated indolizines under mild conditions.
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